FCAS2 Is a mutation of the NLRP12 gene.
FCAS2 is Familial Cold Autoinflammatory Syndrome Type 2
There are 26 confirmed patients globally
There are two or three cases in the UK
There are between six to eight thousand Rare Diseases
They all have serious challenges for patients and families.

What is FCAS2?

FCAS2 is short for Familial Cold Autoinflammatory Syndrome Type 2. It is a mutation of the NLRP12 gene. It is ultra-rare with about 26 confirmed cases globally and two or three in the UK. Find out more.

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Autoinflammatory Conditions


FCAS2 is one of a number of autoinflammatory conditions. Most are very debilitating, painful and lifelong conditions for the patients. Find out more.

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Rare Diseases

There are between 6-8,000 rare diseases. 80% are genetic and caused by faulty genes. It is not rare to have a rare disease. 1 in 17 people will have a rare disease in their lifetime. Find out more.

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